DREAMhub is the dissemination site for the Distributed and Rapid Experimental Automation Machine (DREAM) BioFoundry which aims to use artificial intelligence (AI)-based algorithms to accelerate and automate the design of synthetic biology technologies to address societal-scale challenges. DREAM will also democratize access to cutting-edge AI-directed synthetic biology needed to help solve society’s most pressing challenges in sustainability, agriculture, and health. To that end, the development of DREAM includes the creation of novel computational techniques, experimental workflows, and large biological data sets that will be shared via this website.